High proliferation index (Ki67 ≥ 70%) on immunohistochemistry. B (Bulky): Physical presence of a tumor mass ≥ 7.5 cm.
Research indicates that variables like bulky disease and Ki67 are strong independent predictors of how long a patient will remain in remission.
High KBMP4 scores often signal that standard R-CHOP therapy may not be enough, potentially leading to more intensive consolidative strategies or clinical trials.