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CCL28-induced RARβ expression inhibits oral squamous cell ... - PMC

The retinoic acid receptor beta 2 (RARβ2) is a member of the nuclear receptor superfamily that plays a vital role in regulating cell growth, differentiation, and programmed cell death (apoptosis). In many human cancers, the expression of this gene is lost or significantly reduced, which is a key step in the development of tumors. Understanding the mechanisms that silence RARβ2 is essential for developing new strategies to reactivate it and halt cancer progression. J2 rar

Because the silencing of RARβ2 is often epigenetic rather than a permanent genetic mutation, it is potentially reversible. Researchers have explored using DNMT inhibitors and HDAC inhibitors to strip away the chemical blocks and "unlock" the gene. By reactivating RARβ2, it may be possible to restore the body's natural ability to suppress tumor growth, making it a promising focal point for future cancer therapies. CCL28-induced RARβ expression inhibits oral squamous cell