We found that changes in the cellular levels of AKT1 lead to changes in the levels of a set of differentially expressed genes and, Akt isoforms in the immune system - Frontiers
Somatic mutations in AKT, particularly the , alter the PH domain structure, leading to constitutive membrane localization and hyperactivation of downstream effectors like mTOR and ERK1/2. This promotes uncontrolled proliferation and resistance to apoptosis. AKT1 Transcriptomic Landscape in Breast Cancer Cells - MDPI File: AKT_collection_compressed_2022-11-20.zip ...
: Central to cell survival and general growth; its depletion leads to significant transcriptomic shifts in breast cancer cells. We found that changes in the cellular levels