It is the sale of professional-grade products through unauthorized channels like third-party marketplaces or discount websites.

Searching for "opi" often leads to illicit online pharmacies selling prescription opioids. Federal agencies like the and FDA have issued urgent reports about these sites.

Illegal sites typically do not require a prescription , offer deep discounts, or only accept untraceable payments like cryptocurrency .

Many "online pharmacies" selling pills like Oxycodone or Hydrocodone actually ship counterfeit pills laced with fentanyl . In 2024, the DEA seized over 60 million fentanyl pills, noting that just 2mg (two grains of salt) can be fatal.