-demethylase. This enzyme is required to synthesize ergosterol, a vital component of the fungal cell membrane.
-(1,3)-D-glucan, a major polysaccharide responsible for maintaining the structural integrity of the cell wall, causing cell lysis. antifungal agent
: Fluconazole , itraconazole , and voriconazole . 2. Polyenes -demethylase
: This binding creates physical pores or channels in the membrane. Small essential molecules and cellular organelles leak out of these pores, causing cell death. Common Examples : Amphotericin B, nystatin , and natamycin. 3. Echinocandins causing cell lysis. : Fluconazole
: This blocks an early step in ergosterol biosynthesis, leading to a toxic buildup of squalene and depletion of ergosterol. Common Examples : Terbinafine. Antifungal Agents - StatPearls - NCBI Bookshelf - NIH