: She contributed to vital studies in Nature Neuroscience evaluating how liver-expressed (peripheral) apoE4 compromises synaptic plasticity and exacerbates brain amyloid pathology. ⚗️ Focus 2: Akari Yamazaki in Organic Chemistry
She established highly specialized cell isolation procedures to secure glio-vascular cell-enriched single-cell suspensions.
A significant portion of her co-authored work focuses on the apolipoprotein E (APOE) gene—specifically the ε4 allele, which is the strongest genetic risk factor for Alzheimer's disease.
This technique was detailed in the established protocol paper featured in STAR Protocols , which allows researchers to execute high sequencing depth of mouse brain vascular cells to study brain diseases. The Role of ApoE4 and Cerebrovascular Function
: Her research published in journals like Arteriosclerosis, Thrombosis, and Vascular Biology has demonstrated that ApoE in Brain Pericytes regulates endothelial cell phenotype. This showed that ApoE4 impairs the basement membrane formation of capillaries, contributing to cognitive decline.
